科研项目:
1. 主持:国家自然科学基金青年项目,2019.01-2021.12
2. 主持:黑龙江省普通高校青年创新人才培养计划项目,2016.12-2019.11
3. 主持:东北农业大学“东农学者”青年才俊项目,2019.01-2021.12
4. 主持:东北农业大学开放课题,2020.07-2022.06
5. 参与:国家重点研发计划,2017.07-2021.12
6. 参与:国家自然科学基金青年项目,2017.01-2019.12
7. 参与:国家科技重大专项和重点研发项目省级资金,2017.07-2021.12
8. 参与:黑龙江省“百千万”工程科技重大专项,2020.04-2022.12
9. 参与:黑龙江省自然科学基金青年项目,2016.01-2018.12
学术论文
1. Milk fermented with Lactococcus lactis KLDS4.0325 alleviates folate status in deficient mice. Food & Function, 2020.
2. Analysis of the complete genome sequence of Lactobacillus delbrueckii ssp. bulgaricus with post-acidification capacity and its influence on yogurt in storage. J Dairy Sci, 2021.
3. The Protective effects of Lactobacillus plantarum KLDS 1.0344 on LPS-induced mastitis in vitro and in vivo. Frontiers in Immunology, 2021.
4. Immunomodulatory effects of the Bifidobacterium longum BL-10 on lipopolysaccharide-induced intestinal mucosal immune injury. Frontiers in Immunology, 2022.
5. Effects of Lactobacillus acidophilus KLDS1.0901 on proliferation and apoptosis of colon cancer cells. Frontiers in Microbiology, 2022.
6. Identification, characterization, and antioxidant potential of Bifidobacterium longum subsp. longum strains isolated from feces of healthy infants. Frontiers in Microbiology, 2021.
7. Distinct Effects of Milks from Various Animal Types on Infant Fecal Microbiota through in vitro Fermentations. Frontiers in Microbiology, 2020.
8. Effects of carbon concentration, oxygen, and controlled pH on the engineering strain Lactiplantibacillus casei E1 in the production of bioethanol from sugarcane molasses. AMB Express, 2021.
9. Lactic acid production by fermentation of soybean molasses with lactic acid bacteria and carbohydrate metabolism. Food Science, 2018.
10. Epigallocatechin gallate (EGCG) modification of structural and functional properties of whey protein isolate. Food Research International, 2022.
11. Characterization of Microbiota of Naturally Fermented Sauerkraut by High-throughput Sequencing. Food Science and Biotechnology, 2022.
12. Modification of whey− soybean mixed protein by sequential high-pressure homogenization and transglutaminase treatment. LWT, 2022.
13. 大豆肽的硅藻土脱色工艺优化. 中国油脂,2020.
14. Genomic and in vitro properties of the dairy Streptococcus thermophilus SMQ-301 strain against selected pathogens. Food & Function, 2021.
15. Effects of microbiota-directed supplementary foods on gut microbiota in fecal colonized mice of healthy infants. Journal of Functional Foods, 2022.
16. Alleviation effects of Bifidobacterium animalis subsp. lactis XLTG11 on dextran sulfate sodium-induced colitis in mice. Microorganisms, 2021.
17. In vitro and in vivo evaluation of an exopolysaccharide produced by Lactobacillus helveticus KLDS1.8701 for the alleviative effect on oxidative stress. Food and Function, 2019.
专利:
(1) 霍贵成; 徐敏; 王松 ; 一种治疗溃疡性结肠炎的药物及其制备方法, 2015-11-23, 中国, CN201510810779.8 (专利)
(2) 李柏良; 史佳鹭; 刘飞; 赵莉; 王松; 霍贵成 ; 一种预防和治疗溃疡性结肠炎的混合乳杆菌及其应 用, 2020-12-10, 中国, CN202011458234.2 (专利)
(3) 李柏良; 王娜娜; 李娜; 闫芬芬; 刘飞; 王松; 霍贵成 ; 植物乳杆菌KLDS1.0386与色氨酸混合物在制 备预防结肠炎的药物中的应用, 2020-5-28, 中国, ZL202010465441.4 (专利)
(4) 李柏良; 李慧臻; 柯楚新; 刘飞; 王松; 霍贵成 ; 一种预防急、慢性酒精性肝损伤的乳酸菌配方及其 应用, 2020-5-28, 中国, ZL202010465442.9 (专利)
(5) 霍贵成; 赵莉; 李柏良; 董家欢; 刘德玉; 徐宝峰; 刘飞; 王松 ; 具有预防及缓解结肠炎症状的长双歧杆菌长亚种及其应用, 2021-9-30, 中国, ZL202111162772.1 (专利)
技术转化:
一种含有益生菌的大豆寡糖产品的制备方法, 软著, 技术转让, 广东金海康医学营养品股份有限公司, 10.0000万元, 2022-08-30 (成果技术转移)